Youth involved in 4-H projects have been engaged in science-related endeavors for years. Since 2006, 4-H has invested considerable resources in the advancement of science learning. The new Minnesota 4-H Science of Agriculture Challenge program challenges 4-H youth to work together to identify agriculture-related issues in their communities and to work with local experts, using scientific and engineering principles, to devise real solutions for those issues. The Minnesota 4-H Science of Agriculture Challenge program has the potential to change the way scientific and engineering principles are integrated into 4-H youth development programming.