School-located vaccination has a long history in the United States. The 2008 Advisory Committee on Immunization Practices (ACIP) recommendation for annual influenza vaccination of all children 6 months through 18 years of age adds approximately 30 million individuals to the overall cohort recommended to have a yearly vaccination. The ability to administer this vast number of vaccinations may be beyond the capacity of primary care providers, leaving schools as an attractive venue for mass immunization clinics.