The purpose of this study is to present the whole process step-by-step of how a science lesson can be planned and implemented based on Multiple Intelligences (MI) theory. First, it provides the potential of the MI theory for science teaching and learning. Then an MI science lesson that was developed based on a modified model in the literature and implemented in an 8th grade classroom is given as a concrete example in order to help preservice and inservice science teachers to create bridges from the theoretical framework of the MI theory into classroom practice. This study uncovers that there are four important factors affecting how MI science lessons are planned and carried out. They are: (1) identifying individual students' multiple intelligences or strengths via a reliable and valid tool, (2) paying attention to the literature findings related to students' difficulties in learning the relevant science topic, (3) considering the nature of the knowledge structure that students are supposed to learn with respect to the MI, and (4) examining teacher's ability to manage the MI activity. (Contains 1 footnote.)