Adolescence is a time of transition, marking a period in which a teen's sexuality is developing physically and emotionally. A parent's job is to help children understand these feelings and how to respond safely and appropriately. While sexuality is important for both boys and girls, many issues are unique to females. Young girls with seizures need to learn how evolving hormonal changes may affect seizures as well as how their epilepsy may affect their sexual lives and other gender-specific health concerns. This article introduces the relationship between hormones and epilepsy and how seizures and medications may affect sexual function, contraception, and having children. The importance of counseling girls early on sexuality and family planning is reinforced. (Contains 1 table.)