This study aimed at adapting the Questionnaire Quality of Life in Epilepsy (QOLIE-89 version 1.0: Vickrey et al., 1993), Quality of Life in Epilepsy QoLIE-89 RAND (Santa Monica, CA)] so that it may be used to measure quality of life (QoL) of older adults, healthy or suffering from various chronic illnesses. The participants were 202 older adults recruited from the Pathology Clinic of a general hospital in Thessaloniki, Greece, and from Community Centers for Older adults. The mean age was 71 years. Of them, 51 suffered from diabetes, 50 from cardiovascular disease, 52 suffered from arthritis/myoskeletal diseases, and 49 were healthy. The QOLIE-89 inventory comprises 89 items that measure 17 topics. Exploratory factor analysis revealed 3 factors, namely, health (i.e., physical health and functioning), cognition, and social behavior. Cronbach's a for the various topics in each group of participants ranged from 0.60 to 0.90 with a number of exceptions with very low a. Concurrent validity was tested through correlations with measures of subjective well being, affect, life satisfaction, and adaptation to old age. A series of ANOVAs showed differences between the healthy and the chronic illness groups of participants but no clearcut differences between the three chronic illness groups. Further study on the adaptation of QOLIE-89 is needed so that its potential as a general measure of QoL in older adults is determined.