The validity of scores on the Strong Interest Inventory (SII) for Asian American college students has not been thoroughly investigated. This study examined the evidence of validity of the SII Occupational Scale scores for predicting college major choices of Asian American women and men and White women and men. The sample included 186 female and 133 male college students. Forty-six percent of the sample was Asian American and 54% was White. Acculturation also was tested for its moderating effect on predictive accuracy of the SII scores for Asian American participants. In aggregate the results support the use of the SII with Asian American college students. (Contains 4 tables.)