The University has a remarkably enduring history that is due in no small part to its ability to adapt itself whenever intellectual, political, or technological change has occurred. Today's technology revolution, however, presents the University with one of the greatest adaptation challenges it has ever faced in its lengthy history, and the Institution will either adjust to this new reality or will risk losing its status as a premier educational institution. Instructional technology can play a critical role in helping the University meet these new challenges, but how should instructional technology be effectively leveraged to do so? Key recommendations are presented and discussed.