Based on work with state and local education agencies in dropout prevention for students with disabilities, successful research-based interventions are described along with details of how these interventions have been implemented in middle and high schools across the country. The interventions that have helped students with disabilities graduate from school include early warning systems, mentoring programs, student engagement, family engagement, academic remediation and enrichment, career-focused curricula, interpersonal skills instruction, a focus on the transition to high school, and class/school restructuring initiatives.