A meta-analysis by Tran, Sanchez, Arellano, and Swanson (2011) of the published RTI literature found that the magnitude of effect size (ES) between responders and low responders at posttest was significantly moderated by the pretest ES and the type of dependent measure administered, whereas no significant moderating effects were found in the mixed regression analyses for number of weeks of intervention, length of sessions, number of sessions, type of intervention (one-to-one vs. small-group instruction), and criteria for defining responders (cutoff, scores, discrepancy, benchmark). Overall, the synthesis questions whether the published evidence on RTI related to classifying responders and nonresponders at posttest has shown to be adequately separated from pretest learner characteristics. Stuebing et al. (2012) provided an excellent critique of this meta-analysis and raised at least four major issues related to interpreting the outcomes. In this commentary, the author presents their responses to these concerns.