This ex-post facto designed study investigated the extent of Deans and Heads of Departments' effectiveness in managing research output for knowledge creation in South-South Nigerian universities. One research question and one hypothesis were drawn along the four dimensions of knowledge creation namely: socialization, combination, externalization and internalization to give direction to this study. A stratified random sample of 46 Deans and 154 Heads of Departments constituted the sample size, totaling 200 drawn from a population of 320 Deans and Heads of Departments from four (4) Federal Universities located in the zone. Data collection was carried out with the use of researchers-constructed instrument called "Research Output Management for Knowledge Creation Questionnaire (R.O.M.K.C.Q.)". Data collected were analyzed with descriptive statistics comprising mean rating and Independent t-test. Results obtained indicated that Deans and H.O.Ds were effective in managing research output for knowledge creation in terms of knowledge socialization, knowledge combination and knowledge externalization, but were not effective in knowledge internalization. Deans and H.O.Ds differed significantly in managing research output for knowledge creation in terms of knowledge socialization, but do not in knowledge combination, knowledge externalization and knowledge internalization. It was recommended that Deans and H.O.Ds should intensify their efforts in managing research output for knowledge creation.