This study aimed to measure whether self-esteem and social support are mediators in the relationship between loneliness and life satisfaction. The study includes early teenagers from the 6th, 7th and 8th grades aged between 11 and 15 (M = 13.31, SD = 1.09). The study group consisted of 431 secondary school students from large and medium sized cities in Turkey, of which 196 (44.5%) were girls and 235 (54.5%) were boys. The study examined students' responses to life satisfaction, loneliness, self-esteem and social support scales. Data were separated into parcels of instruments within the framework of structural equation modeling. It was determined that both self-esteem and social support were partial mediators between loneliness and life satisfaction. These results are discussed within the scope of the literature.