The logistic person response function (PRF) models the probability of a correct response as a function of the item locations. Reise (2000) proposed to use the slope parameter of the logistic PRF as a person-fit measure. He reformulated the logistic PRF model as a multilevel logistic regression model and estimated the PRF parameters from this multilevel framework. An advantage of the multilevel framework is that it allows relating person fit to explanatory variables for person misfit/fit. We critically discuss Reise's approach. First, we argue that often the interpretation of the PRF slope as an indicator of person misfit is incorrect. Second, we show that the multilevel logistic regression model and the logistic PRF model are incompatible, resulting in a multilevel person-fit framework, which grossly violates the bivariate normality assumption for residuals in the multilevel model. Third, we use a Monte Carlo study to show that in the multilevel logistic regression framework estimates of distribution parameters of PRF intercepts and slopes are biased. Finally, we discuss the implications of these results and suggest an alternative multilevel regression approach to explanatory person-fit analysis. We illustrate the alternative approach using empirical data on repeated anxiety measurements of cardiac arrhythmia patients who had a cardioverter-defibrillator implanted. (Contains 2 tables and 4 figures.)