This article introduces the Major Contribution on integrating health and vocational psychology, using persons with HIV who have work-related concerns as an example. The authors describe the demographics associated with HIV disease and new treatments that have allowed people with HIV to remain healthy and continue working, or consider returning to work. They also outline the purposes of the Major Contribution and conclude with a call for more focus on traditionally disenfranchised populations, especially those who are members of multiple groups facing discrimination.