The purpose of this study was to determine the effects of interactive multimedia simulations and virtual dissection software on depth of learning among students participating in biology and chemistry laboratory courses. By understanding more about how simulation and virtual dissection software changes depth of learning, educators will have the ability to add these modalities to their current instructional design. The research problems for this study were designed to answer two questions: first, what effect does the use of interactive multimedia simulation software have on the depth of learning within science laboratories? and second, what effect does the use of virtual dissection software have on the depth of learning within science laboratories? A comparative methodology was utilized to collect pretest and posttest data to assess depth of learning for four sampling periods in Introduction to Chemistry and General Biology laboratories. Pretest and posttest statistical comparison was completed via paired "t" tests, independent sample "t" tests, and analysis of variance. Statistical findings showed significant differences between participants in their depth of learning after utilizing interactive multimedia simulations in introduction to chemistry. No significant differences were found within general biology participants after utilizing the interactive multimedia simulations. Statistical findings showed significant differences between participants in their depth of learning after utilizing virtual dissection software. These results indicate that participants changed their depth of learning after completing simulation and virtual dissection software when compared to "wet" laboratories learning environments. The research study findings will allow for an instructional design to establish and to use specific simulation and virtual dissection software as components of a science laboratory learning environment. Overall, the use of simulation and virtual dissection software in coordination with any instructional design model will allow science educators to create a learning environment that promotes an increase in depth of learning. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]