In this article we examine gender differences in factors related to science, technology, engineering, mathematics, and medicine (STEMM) education and employment between the ages of 36 and 39. Using data from the Longitudinal Study of American Youth, we identified a STEMM high school talent pool. We found early gender differences in interest in engineering, although we found no such differences in entry into a general STEMM undergraduate major. Throughout the course of the study, we developed and tested structural equation models. We discovered that there were no major gender differences in family encouragement or precollege educational experiences, except that high school boys were slightly more likely to take calculus in high school. There were no significant differences in entrance into medicine and other health professions, but there were substantial gender differences in earned engineering degrees and employment in engineering. The completion of a graduate or professional degree was a stronger predictor of female employment in a STEMM profession than for young men. Among young adults with academic qualifications for a STEMM profession, the presence of children 18 years of age or younger in the family made no difference in the likelihood of employment in a STEMM profession. (Contains 4 tables, 2 figures and 2 footnotes.)