A socioscientific issues integrated instruction was used in the study to resolve college students attitude towards sexually-themed science content. Some 200 college students participated in the study as experimental and control groups. The former consisting of 98 students from one college was taught the content using the socioscientific issues integrated instruction. The later with 102 students from another college was taught the same content using a traditionally teacher dominated lectures. Both groups were taught over a period of eight weeks. Qualitative and quantitative data were obtained before and after the intervention. The quantitative data were analysed using analysis of covariance. The results revealed that there was a significant difference between the experimental and the control groups (F (1, 247) = 426.97, p = 0.00, partial eta squared = 0.64) where the experimental group showed a significant change in attitude towards the content studied. The qualitative data obtained some experimental group students showed a change in attitude the second interview. It was concluded that the use of the approach has significantly made the college students feel comfortable and confident to learn and teach the content.