The contribution of the e-textbooks can be enormous considering their additional supporting features, but adoption has not crystallized yet. This study examines the relevant experiences of college students in terms of how the use of e-textbooks may enhance their learning. A survey study was conducted to measure the perceptions of each student on how helpful an e-textbook is for facilitating learning (i.e., E-book Helpfulness), how well it promotes his/her involvement in learning (i.e., Student Involvement), and how much improvement it makes on learning outcome (i.e., Learning Outcome). Results indicate that e-textbooks are perceived as enhancers of student learning experiences in two complementing routes: (1) E-textbook Helpfulness enhances students' learning outcomes directly and (2) Student Involvement plays an important mediating role between E-textbook Helpfulness and Learning Outcome if students use e-textbooks in class. These findings suggest that the successful adoption of e-textbooks requires schools to provide necessary resources (e.g., computer labs) and instructors to actively engage students in using e-textbooks.