The primary goal of this study was to examine the word identification domain of the Simple View of Reading in participants with Down syndrome (DS) by comparing them to participants with typical development (TD) matched on word identification ability. Two subskills, phonological recoding and orthographic knowledge, were measured. Results revealed that individuals with DS performed similarly to controls on 2 measures of orthographic knowledge, but more poorly on phonological recoding and a third measure of orthographic knowledge. The first two orthographic tasks included real words as stimuli; the third task used letter patterns, not real words. These results suggest that individuals with DS may have a relative strength in word-specific orthographic knowledge but not in general orthographic knowledge.