This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university can deliver. That includes a course Web site far more extensive and interactive than undergraduates usually encounter, with texts, images, artwork, music, a library's worth of geographic, cultural, and historical resources, and even a virtual ship tour. The digital elements are not just a song and dance to keep students entertained. They are a vessel for Mr. Greenblatt's latest scholarly thinking. More than that, they are a central element in the university's campaign to refashion teaching in the humanities. Harvard has entered the final stage of its multiyear evolution from the static core-curriculum model to what it hopes will be a hands-on, interdisciplinary species of general education. With its blend of digital innovation and scholarship, "Travel and Transformation" may be the humanities course of the future.