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Direct linkLoo, Sandra K.; Hale, T. Sigi; Hanada, Grant; Macion, James; Shrestha, Anshu; McGough, James J.; McCracken, James T.; Nelson, Stanley; Smalley, Susan L. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: The current study tests electroencephalogram (EEG) measures as a potential endophenotype for attention deficit/hyperactivity disorder (ADHD) by examining sibling and parent-offspring similarity, familial clustering with the disorder, and association with the dopamine receptor D4 (DRD4) candidate gene. Method: The sample consists of 531…
Descriptors: Attention Deficit Hyperactivity Disorder, Siblings, Medicine, Genetics
Belsky, Jay; Pluess, Michael – Child Development, 2013
Data from 508 Caucasian children in the NICHD Study of Early Child Care and Youth Development shows that the DRD4 (but not 5-HTTLPR) polymorphism moderates the effect of child-care quality (but not quantity or type) on caregiver-reported externalizing problems at 54 months and in kindergarten and teacher-reported social skills at kindergarten and…
Descriptors: Child Development, Personality, Infants, Genetics
Maxwell, Allison – Journal of Attention Disorders, 2013
Some studies conducted on ADHD have found a statistically significant relationship between those diagnosed with the disorder and a higher susceptibility to abuse alcohol. However, other studies have found no such correlation, or have found this to be true of only a nonstatistically significant subset of the population of individuals with ADHD.…
Descriptors: Attention Deficit Hyperactivity Disorder, Alcohol Abuse, Genetics, Brain
Martel, Michelle M.; Nikolas, Molly; Jernigan, Katherine; Friderici, Karen; Nigg, Joel T. – Journal of Abnormal Child Psychology, 2012
Oppositional-Defiant Disorder (ODD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are highly comorbid, a phenomenon thought to be due to shared etiological factors and mechanisms. Little work has attempted to chart multiple-level-of-analysis pathways (i.e., simultaneously including biological, environmental, and trait influences) to ODD and…
Descriptors: Behavior Disorders, Attention Deficit Hyperactivity Disorder, Organizations (Groups), Conflict
Belsky, Jay; Pluess, Michael; Widaman, Keith F. – Journal of Child Psychology and Psychiatry, 2013
Background: Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method: We present and illustrate a new regression technique…
Descriptors: Genetics, Environmental Influences, Interaction, Statistical Analysis
Kegel, Cornelia A. T.; Bus, Adriana G.; van IJzendoorn, Marinus H. – Mind, Brain, and Education, 2011
Not every child seems equally susceptible to the same parental, educational, or environmental influences even if cognitive level is similar. This study is the first randomized controlled trial to apply the differential susceptibility paradigm to education in relation to children's genotype and early literacy skills. A randomized pretest-posttest…
Descriptors: Control Groups, Intervention, Intelligent Tutoring Systems, Computer Software
Altink, Marieke E.; Arias-Vasquez, Alejandro; Franke, Barbara; Slaats-Willemse, Dorine I. E.; Buschgens, Cathelijne J. M.; Rommelse, Nanda N. J.; Fliers, Ellen A.; Anney, Richard; Brookes, Keeley-Joanne; Chen, Wai; Gill, Michael; Mulligan, Aisling; Sonuga-Barke, Edmund; Thompson, Margaret; Sergeant, Joseph A.; Faraone, Stephen V.; Asherson, Philip; Buitelaar, Jan K. – Journal of Child Psychology and Psychiatry, 2008
Background: The dopamine receptor D4 ("DRD4") 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by…
Descriptors: Siblings, Smoking, Attention Deficit Hyperactivity Disorder, Pregnancy
Bakermans-Kranenburg, Marian J.; Van Ijzendoorn, Marinus H.; Pijlman, Femke T. A.; Mesman, Judi; Juffer, Femmie – Developmental Psychology, 2008
In a randomized controlled trial we tested the role of genetic differences in explaining variability in intervention effects on child externalizing behavior. One hundred fifty-seven families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior participated in a study implementing Video-feedback…
Descriptors: Intervention, Discipline, Hyperactivity, Attention Deficit Disorders
Beaver, Kevin M.; Vaughn, Michael G.; Wright, John Paul; DeLisi, Matt; Howard, Matthew O. – Intelligence, 2010
Although academic achievement is a heritable construct, to date research has yet to explore its molecular genetic underpinnings. Drawing on data from the National Longitudinal Study of Adolescent Health, the current longitudinal study investigated the associations between polymorphisms in three dopaminergic genes (DAT1, DRD2, and DRD4) and…
Descriptors: Academic Achievement, Adolescents, Genetics, Middle School Students
Luijk, Maartje P. C. M.; Roisman, Glenn I.; Haltigan, John D.; Tiemeier, Henning; Booth-LaForce, Cathryn; van IJzendoorn, Marinus H.; Belsky, Jay; Uitterlinden, Andre G.; Jaddoe, Vincent W. V.; Hofman, Albert; Verhulst, Frank C.; Tharner, Anne; Bakermans-Kranenburg, Marian J. – Journal of Child Psychology and Psychiatry, 2011
Background and methods: In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems ("DRD4", "DRD2", "COMT", "5-HTT", "OXTR") on attachment security and disorganization.…
Descriptors: Child Rearing, Infants, Attachment Behavior, Rating Scales
Brody, Gene H.; Chen, Yi-fu; Beach, Steven R. H. – Journal of Child Psychology and Psychiatry, 2013
Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than…
Descriptors: Prevention, Genetics, Drinking, At Risk Persons
Gibbons, Frederick X.; Roberts, Megan E.; Gerrard, Meg; Li, Zhigang; Beach, Steven R. H.; Simons, Ronald L.; Weng, Chih-Yuan; Philibert, Robert A. – Developmental Psychology, 2012
The impact of 3 different sources of stress--environmental, familial (e.g., low parental investment), and interpersonal (i.e., racial discrimination)--on the life history strategies (LHS) and associated cognitions of African American adolescents were examined over an 11-year period (5 waves, from age 10.5 to 21.5). Analyses indicated that each one…
Descriptors: Sexuality, Adolescents, Racial Discrimination, Biographies
Loo, Sandra K.; Rich, Erika Carpenter; Ishii, Janeen; McGough, James; McCracken, James; Nelson, Stanley; Smalley, Susan L. – Journal of Child Psychology and Psychiatry, 2008
Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of…
Descriptors: Siblings, Attention Deficit Disorders, Hyperactivity, Genetics
Laucht, Manfred; Becker, Katja; Schmidt, Martin H. – Journal of Child Psychology and Psychiatry, 2006
Background: The present study was designed to investigate the association between visual exploratory behaviour in early infancy, novelty seeking in adolescence, and the dopamine D4 receptor (DRD4) genotype. Methods: Visual attention was measured in 232 three-month-old infants (114 males, 118 females) from a prospective longitudinal study using a…
Descriptors: Evidence, Attention, Infants, Males
Raby, K. Lee; Cicchetti, Dante; Carlson, Elizabeth A.; Egeland, Byron; Collins, W. Andrew – Journal of Child Psychology and Psychiatry, 2013
Background: Longitudinal research has demonstrated that individual differences in attachment security show only modest continuity from infancy to adulthood. Recent findings based on retrospective reports suggest that individuals' genetic variation may moderate the developmental associations between early attachment-relevant relationship…
Descriptors: Longitudinal Studies, Attachment Behavior, Security (Psychology), Genetics
