It was proposed that an analysis of the questions students anticipate asking, and ask, could provide information about an enculturation encounter between Year 13 biology students and scientists working in a biomedical-clinical research unit. As part of a day-long intervention at this research institute, small groups of students (10-15) met with scientists (two) for a 15-minute discussion period. Pre- and post-questionnaires from 398 students provided data on intended, and judged best questions that were categorised and analysed into five categories: nature of science, science information, citizen decisions, personal, and no response/other. Chi Square analysis showed that students' areas of interest shifted to a personal perspective as a result of the intervention. Twenty students were interviewed who provided explanations for their questions. Analysis of their responses showed students were: developing an understanding of scientific practice as a journey, making identity links, using the personal as a knowledge bridge, acknowledging a commonality of values, and demonstrating that such an enculturation can be a transformative experience. These students engaged with a community of scientists at a physical, cognitive, and personal level. Physically they engaged with the practice of science in the laboratory, cognitively they were able to develop an understanding about how science knowledge was developed, and personally they were able to identify with science and scientists. The shift in students' questions showed that the intervention influenced their views on science and scientists to a broader understanding of scientific literacy. (Contains 3 notes and 3 tables.)