This article discusses the emergence and significance of new knowledge configurations within the Dutch agri-food context. Knowledge configurations can be characterised as arrangements between VET and (often regional) partners in business and research aimed at improving knowledge transfer, circulation or co-creation. Based on a literature review and an empirical study involving 18 knowledge management experts and 11 exemplary "knowledge configurations" we describe their key characteristics and the factors and guiding principles that contribute to their success or lack thereof. (Contains 1 figure and 6 tables.)