DePaul University has grown in size and stature in the last decade. Chicago's "little school under the El," as DePaul was once known, is now the nation's largest Catholic university and the largest private, nonprofit university in the Midwest. DePaul University restructured its board, enabling it to play an important role in the institution's growth and academic rise. In this article DePaul's president shares some lessons to help other boards as they lead their institutions through rapid and dramatic change.