"The Wheel of Scientific Investigation and Reasoning" (Kramer 1987; Paul and Binker 1992) is a graphic representation of the scientific investigative process. The scientific process is depicted in a wheel rather than in a list because "the process of scientific inquiry can begin from any stage, and that stage may be revisited as often as the particular inquiry requires" (Robinson 2004, p. 791). For the life science unit discussed in this article, the authors used this platform to help students develop a systematic set of inquiry, analytical, and argumentation skills in science. (Contains 3 figures.)