This study examined relationships among selected predictors of violence, including victimization, low conflict management efficacy, hostile anger and drug use in 8th-, 10th-, and 12th-grade adolescents. The study was a secondary analysis of data from a population-based, cross-sectional survey of health behaviors among adolescents (N = 3922). For each cohort, it was hypothesized that victimization and low conflict management efficacy would predict low hostile anger control, which would predict gateway drug use, and the subsequent development of hard drug use and violence. Overall model fit and the magnitude of specific paths were expected to increase across grades. Using structural equation modeling (SEM), results indicated acceptable model fit for 8th-grade (CFI = .95), 10th-grade (CFI = .93) and 12th-grade (CFI = .94) cohorts. Results suggest that the influence of relational victimization and conflict management efficacy on hard drug use may be mediated through low hostile anger control and gateway drug use.