This article includes a current research synthesis on a subpopulation of twice exceptional individuals, those who are academically talented with autism spectrum disorder (ASD). This population is emerging as an increasing focus of research, as the numbers of individuals identified are increasing. A total of 32 articles were included using the study's inclusion criteria, and of these 32 articles, 62.5% presented data, whereas the remaining 37.5% were review or conceptual articles. This review of articles published between 1996 and 2019 suggests little research is being conducted on this population. Some of the research conducted recently involve case studies, others are correlational in nature, and most are descriptive, focusing on participants' characteristics and how they were identified. A wide range of definitions were utilized in the literature, and to date, no empirical research has been published about this population. Implications from the current research base and suggestions for future research are included.