Parents of academically talented students with various types of learning differences, often called 2E, need to understand how support their children's unique needs. In this article, we discuss current research about 2E students and focus on how parents can both nurture and find educational opportunities that encourage their children's strengths and simultaneously address their deficits. Talent development strategies are discussed for parenting for strengths with this population. Too often, 2E students, have conflicting needs that can complicate the identification and development of their talents and so this article concludes with specific recommendations for parents of these students.