Ten scholarly papers and twelve abstracts comprise the content of the twenty-first annual Brick & Click Libraries Conference, held annually at Northwest Missouri State University in Maryville, Missouri. The twenty-first Brick & Click Libraries Conference was held virtually. The proceedings, authored by academic librarians and presented at the conference, portray the contemporary and future face of librarianship. The 2021 paper and abstract titles include: (1 Designing a Library Exhibition Program On an International Scale for Outreach and Research (Danielle De Jagger-Loftus and Sarah Hanson-Pareek); (2) It's Not Busy Work (Veronica Denison and Tara Coleman); (3) Leading from Anywhere (Rebecca Croxton, Anne Cooper Moore, and Sherri Saines); (4) Intentional Design: Crafting a Mutually Beneficial Internship Program in a University Archives and Special Collections (Wendy Guerra, Claire Du Laney, and Lori Schwartz); (5) The Plot Thickens: Writing the Next Chapter for Access Services (Anna Hulsenberg, Michelle Twait, and Leah Zacate); (6) Get on Track, Jack: Library Assessment Strategies (Nancy Marshall, Linda Kott, and Kristin Echtenkamp); (8) Arguing in the Comments: Using Social Media Interactions to Teach the Rhetoric Of Research (Lane Wilkinson); (9) Migrating an Integrated Library System: A Framework for Fulfillment (Janelle Sander); (10) Defending Wonder: Adapting an Archival Tour in a Digital Environment (Laura Michelson, Allison Haack, and Christopher Jones); (11) Mapping Libguides to Students' Learning (Dipti Mehta and Xiaocan (Lucy) Wang); (12) An Uncommon Partnership: Special Collections and Advanced Art History Classes at Missouri State University (Anne M. Baker); (13) OER on Campus When Everyone Else is Off Campus: Strategies to Keep Your OER Program Momentum During a Pandemic (Susan M. Frey and Natalie Bulick); (14) Evaluating Library Resource Subscriptions: A Case Study (David L. Alexander); (15) Preparing Generation Z Student Employees for Productivity: Examples in Academic Library Virtual Training (Michael Straatmann and Kathryn Brockmeier); (16) Ask Them: Improving the International Student Library Experience (Carolyn Johnson); (17) Using an Advisory Board for Student-Driven Assessment (Cori Wilhelm); (18) Bridging the Gap Between The Library and International Students (Leila June Rod-Welch); (19) If I Were the Boss of You… This is How All Meetings Would Be Run (Tara Coleman); (20) Google Sheets in Library Instruction: A Simple Search Activity (Morgan Sederburg); (21) Utilizing Virtual Mini-Escape Rooms to Increase Awareness of Services at an Academic Health Sciences Library (Jessica King); (22) "Good Enough:" Preserving Born-Digital Content on Removable Media with Limited Resources (Dillon Henry). [For the 2020 proceedings, see ED608791.]