Community studies indicating that affluence has social-emotional consequences for youth have conflated family and neighborhood wealth. We examined adolescent boys' delinquency and adolescent girls' anxiety-depression as a function of family, neighborhood, and cumulative affluence in a sample that is primarily of European-American descent, but geographically and economically diverse ("N" = 1,364). Boys in affluent neighborhoods reported higher levels of delinquency and girls in affluent neighborhoods reported higher levels of anxiety-depression compared with youth in middle-class neighborhoods. Neither family affluence nor cumulative affluence, however, placed boys or girls at risk in these domains. Indeed, boys' delinquency and girls' anxiety-depression levels were lowest for those in affluent families living in middle-class neighborhoods. (Contains 4 tables and 1 figure.)