This report summarizes 2010 Profiles data. For each middle or high school that was sampled, the principal and the lead health education teacher (i.e., the person most knowledgeable about health education at the school) each completed a self-administered questionnaire. This report presents information from 47 states, 19 cities, 4 territories, and 2 tribal governments with weighted data from both principal and lead health education teacher surveys and 2 states (Colorado and New Mexico) and 1 territory (Marshall Islands) with weighted data from the principal survey only (Table 1). Principal and lead health education teacher data from Illinois and Puerto Rico were unweighted and are not included in this report. Palm Beach County obtained weighted data but did not grant CDC permission to include their data in this report. This report also examines both long-term (1996-2010) and short-term (2008-2010) trends in school health policies and practices among states and cities with weighted data for both years. (Contains 7 figures and 48 tables.)