Response to Intervention (RtI) is the practice of providing high-quality instruction and interventions to meet student needs and monitor progress in order to ensure effectiveness of instruction and/or interventions. RtI is an integrated service delivery approach for all students and should be applied to decisions in general, remedial, and special education. RtI is the process that all student assistance teams (SATs) in New Mexico must follow to ensure that schools meet all student needs. Response to intervention (RtI) has three fundamental premises: (1) it is a logical structure for allocating precious instructional resources efficiently and targeting them specifically to all student needs; (2) it is a commitment to use the best findings from current and emerging scientific research to go about instruction; and (3) it is a commitment to use a logical, decision-making framework to guide instruction. This manual provides guidance and tools for school districts and charter schools to use in order to build technically sound systems to effectively implement RtI. In New Mexico, all districts, RECs, and charter schools will use the data gathered from the RtI process primarily to evaluate the effectiveness of instruction and intervention; in addition, RtI will provide necessary information and data to guide the possible eligibility determination process for special education services. Response to intervention is the process that all SATs follow before consideration of referral to another program or service is warranted or justified. Key components of the New Mexico RtI model include: (1) Three-tier model for all content areas, including universal screening; (2) Evidenced-based curricula and methodologies for general education, special education, and supplemental progress; (3) Ongoing assessment and progress monitoring of student skills and progress; and (4) Systematic decision rules to move from Tier I to Tier II and Tier II to Tier III, or reverse course. (Contains 4 endnotes, 4 figures and 3 tables.)