In the fall of 2005, the New Mexico Youth Risk and Resiliency Survey (NM YRRS) was conducted in New Mexico public high schools, with 5,679 students in grades nine through twelve participating from 20 public high schools in the state. The NM YRRS is a tool that can assist administrators and policy makers in identifying health risk behaviors among students. The goal is to increase academic success by decreasing health risk behaviors that create barriers to student learning and may contribute to the achievement gap. This report presents the state-level results. Report results indicate that between 2003 and 2005, there was a decrease in alcohol and methamphetamine abuse and smoking among New Mexico high school students. Areas that require the continued attention of state agencies include a high rate of attempted suicide; and overall substance use rates that are higher than national averages. Violence-related behavior, such as carrying a weapon to school or fighting, remained statistically unchanged, as did the percentage of students reporting that they ever had sexual intercourse. The results from the NM YRRS provide the basis for decision-making for the development and implementation of new school health policies and programs, and the justification for funding projects to implement those decisions. As data collection moves ahead in years to come (NM YRRS will be offered in middle schools in the spring of 2007 and in the high schools again in the fall of 2007), meaningful long term trends will be identified, increasing the utility of the survey data to positively impact the lives of New Mexico's youth and the health of all New Mexicans. Three appendixes include: (1) 2005 YRRS Survey Results; (2) Survey Methods; and (3) Data Tables. (Contains 33 figures and 5 tables.) [The production of this report was funded through the University of New Mexico Center for Health Promotion and Disease Prevention (UNM CHPDP), with funding from the New Mexico Department of Health (NMDOH) and the CDC-DASH, through the New Mexico Public Education Department (NMPED).]