This learning module aims to engage students in problem solving, critical thinking, scientific inquiry, and cooperative learning. The module is appropriate for use in any introductory or intermediate undergraduate course that focuses on human-environment relationships. The module states that human health is a product of complex interactions among population, environment, technology, and culture, all of which are affected by global change. It explains that, for example, changes in climate or land use/land cover can affect the reproductive cycles of arthropods that transmit disease, the availability of water for hygiene and sanitation, and/or the concentration of chemical pollutants in the air, water, and soil. It also states that infectious diseases, which cause more than half the mortalities in tropical developing countries and are resurgent in developed ones, are also potentially affected by global environmental changes. According to the module, changes associated with urbanization, globalization, and population growth and mobility encourage disease diffusion and a globalization of health risks. The module introduces students to these issues and illustrates the complex relationships among human health and global change. The module contains 5 tables, 6 figures, a list of acronyms, a guide, a summary, an overview, a glossary, references for all units, supporting materials, and appendixes with additional sources. It is divided into thematically coherent units, each of which consists of background information, teaching suggestions, and student worksheets. (BT)