Two studies have reported that low self-esteem is related to the holding of four specific irrational beliefs; further studies have suggested that these and other irrational beliefs are associated with different client problems. This study attempted to replicate the self-esteem findings with a younger population and improved controls and to explore whether other client problems derive from similar or different irrational beliefs. High school students (N=90) completed self-report measures of irrational beliefs, self-esteem, depression, facilitative anxiety, debilitative anxiety, neuroticism and extraversion. Teacher ratings of self-esteem behaviors and cumulative grade-point-averages were also obtained. Regression analyses indicated that: (1) demand for approval and anxious overconcern were again found to predict low self-esteem; (2) theoretically-appropriate divergent relationships occurred on the control measures; and (3) low self-esteem and other client problems are characterized by both common and unique sources of irrationality. Overall, these findings seem to indicate that certain irrational beliefs are discriminantly predictive of a variety of clinical problems, including low self-esteem, depression, anxiety and neuroticism. A practical application of these findings would be to tailor a structured cognitive therapy intervention program to target the specific irrationalities associated with the client problem. (Author/ABL)