This resource manual and guide provides schools and communities with the most current research-based information available concerning alcohol and drug abuse prevention education. It also provides model lessons, written by Oregon teachers, to infuse into current programs. The document is organized into four sections. The first, an introduction, defines curriculum infusion; describes 10 content and skill areas essential to a K-12 alcohol and drug abuse prevention program; presents notes to the teacher on using the curriculum ideabook; and includes a sample lesson. Special needs students, who may be at greater risk of pressure to use drugs are discussed and provision is offered to fulfill the curriculum requirements for this population utilizing modified content, testing methods, instructional methods, materials, and pacing. The second section examines program planning, implementation, and evaluation. Section three divides students into grade levels K-1, 2-3, 4-5, 6-8, 9-12, provides an introduction to each level, and includes matrices describing content and subject infusion as well as lesson plans, all designated by grade level. The final section lists teacher resources. (LL)