The focus of this document is upon zetetics, the science of research and artistic activity, and its role: to study the origin, growth, and transitions of human knowledge as a whole. The choice and allocation of subject matter within the curriculum is one of the central domains of expertise required of the general curriculum specialist. No matter how curriculum content is conceived or incorporated into the curriculum, the body of accumulated knowledge found in the established disciplines and fields of study associated with formal inquiry needs to be explored. In a comprehensive attempt to identify and order the "totality of recorded systematized knowledge," this document lays out 12 distinct areas in which research and creative activity have been built up and made available. Detailed discussions are presented on the following topics: (1) Zetegeny--the emergence and growth of the arts and sciences as an evolutionary process; (2) Taxilogy--developing an inventory of the zetetic system of knowledge and methods of detecting gaps in knowledge; (3) Problematology--the selection and formulation of problems; (4) Zetesis--the ability needed to do research and creative activities; and (5) General Methodology--the methods of research and terminology common to all disciplines. (JD)