This manual provides a substance abuse prevention curriculum for preschoolers that includes numerous activities that can be used in traditional learning centers. Unit One helps caregivers examine their style of interacting with young children and identify strategies that will facilitate children's problem solving, critical thinking, and decision making. Unit Two helps preschool students value and appreciate their bodies by providing them with a collection of activities designed to introduce, reinforce, and master good mental and physical health and safety practices. Unit Three is designed to approach substance abuse from a basic information point of view that focuses on activities that introduce and reinforce knowledge about alcohol and nicotine. Students are introduced to terms commonly associated with illegal drugs, including crack, cocaine, heroin, and marijuana. Major goals of Unit Four include teaching children about family and community support systems that help children with problems. The unit also aims to reinforce and integrate previously presented concepts. Unit Five collects activities that help children develop self-image and self-concept and increase awareness of substance abuse. Unit Six focuses on the development of positive self-image through feelings. Related materials are appended. (RH)