A recent development in the field of personality assessment has been increasing interest in the use of the Millon Clinical Multiaxial Inventory (MCMI) in clinical settings. The MCMI Scales 1 (Schizoid), 2 (Avoidant), 3 (Dependent), and 8 (Passive-Aggressive) appear to be a possible measure of initial stress in certain psychiatric inpatients. To examine the prevalence of the 1-2-3-8 codetype profile pattern among psychiatric inpatients, the MCMI profiles for 131 psychiatric inpatients were subjected to analysis. Thirty-five of the 131 subjects had profiles in which scales 1,2,3, and 8 were the four highest scales. Analysis of the diagnoses and clinical records of these patients suggest that this profile reflects an affect/mood disturbance with prominent depressive features and suicidal ideation/attempt prior to admission. This investigation serves mainly as a stimulus for research questions that should be addressed in order to increase the range of clinical applications of the MCMI and the body of empirical literature that can support the utility of this assessment device. (NB)