This report contains a proposed agenda for the comprehensive study of United States science policy which the Committee on Science and Technology expects to perform during the 99th Congress. The proposed agenda was developed by the committee's Task Force on Science Policy in response to the charge to focus on the issues of maintaining America's leadership in science in view of the changing environment facing the nation during coming decades. The proposed agenda is broad and raises questions about both the basic purposes of federal funding for scientific research and the specific practices of the governmental agencies for the expenditures of those funds. Topics included in the agenda are organized under 10 major subject categories (and subcategories, when applicable). These categories are: goals and objectives of national science policy; the institutional framework for the conduct and support of research; education and manpower (including the past, present, and future government role in science education); impact of the information age on science; role of the social and behavioral sciences; the regulatory environment for scientific research; funding levels; support of science by the mission agencies (including the Department of Defense); funding mechanisms; and the role of the congress in science policy making. (JN)