Self-instructional Mediated Learning Modules (MLMs), audiotaped or videotaped units based upon a structured learning approach, may be used by clinics to provide effective, low-cost psychological treatments to large numbers of people. MLMs produced by the Life Skills Training Project focused on interpersonal and self-management skills. Nine experiments were conducted to compare the self-instructional MLM to various placebo control treatments, using undergraduates as subjects. Assertive behavior, knowledge of rights, conversational skills, dating behavior, self disclosure, response to criticism, discriminating between responses, cognitive restructuring, and problem solving were assessed; behavioral performance ratings were used as the primary dependent measure. Self-instructional MLMs were more effective than the placebo treatments in producing higher performance ratings for interpersonal and self-management skills in behavioral role-play situations. Some evidence appeared to be related to generalization, maintenance, and the effects of the target behaviors in achieving desired interpersonal outcomes. MLMs may have promise for advancement of theory and research methods as well as provision of a low-cost delivery system for psychological services. (Author/NRB)