This reference guide is designed to organize and suggest acceptable practices and procedures for dealing with safety in the area of biology instruction. It is intended as a reference for teachers, administrators, and other school staff in planning for science activities and in making daily safety decisions. Discussions deal with responsibility for safety, microbes, use of plant materials, use of animals, laboratory activities with humans, safety glasses, use of laboratory equipment and supplies, field trips, high risk experiments, special activities, emergencies, and recommendations. Numerous appendices deal with specialized considerations. (RE)