ERIC Number: EJ747471
Record Type: Journal
Publication Date: 2007-Jan
Reference Count: 10
Case Report. Prevention of Clozapine-Induced Granulocytopenia/Agranulocytosis with Granulocyte-Colony Stimulating Factor (G-CSF) in an Intellectually Disabled Patient with Schizophrenia
Rajagopal, G.; Graham, J. G.; Haut, F. F. A.
Journal of Intellectual Disability Research, v51 n1 p82-85 Jan 2007
Background: While clozapine is an effective treatment for refractory schizophrenia, its use is limited by haematological side effects. Treatment options that allow continued prescription of clozapine by tackling these side effects will greatly aid patients for whom this medication is all too often their only hope of recovery. Method: In this case report, we describe what we believe are two "firsts" in the clozapine literature: the use of granulocyte-colony stimulating factor on a "prophylactic" basis in an "intellectually disabled patient" receiving clozapine for refractory schizophrenia. Result: Treatment with granulocyte-colony stimulating factor prevented discontinuation of clozapine, enabling our intellectually disabled patient's recovery from a schizophrenic illness.
Descriptors: Patients, Schizophrenia, Drug Therapy, Clinical Diagnosis, Improvement Programs, Outcomes of Treatment, Medical Research, Research Reports
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A