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ERIC Number: EJ921615
Record Type: Journal
Publication Date: 2011-Jan
Pages: 5
Abstractor: As Provided
ISSN: ISSN-0021-9584
Isothermal Titration Calorimetry in the Student Laboratory
Wadso, Lars; Li, Yujing; Li, Xi
Journal of Chemical Education, v88 n1 p101-105 Jan 2011
Isothermal titration calorimetry (ITC) is the measurement of the heat produced by the stepwise addition of one substance to another. It is a common experimental technique, for example, in pharmaceutical science, to measure equilibrium constants and reaction enthalpies. We describe a stirring device and an injection pump that can be used with a previously described isothermal calorimeter to perform ITC measurements. Two experiments are also described: an acid-base titration and the binding of Ba[superscript 2+] to the macrocyclic compound 18-crown-6. These experiments visualize the difference between strong and weak interactions (large and small equilibrium constants) and introduce how reaction enthalpies and equilibrium constants can be calculated from titration calorimetric experiments. (Contains 3 tables and 7 figures.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A