Cross-border university networks have recently been advocated as an effective strategy for addressing national and regional development needs while simultaneously strengthening the capacity of the participating institutions. While university-to-university partnerships generally involve two institutions collaborating to accomplish a particular activity, university networks typically involve a larger number of institutions and focus on a broader set of activities organised around a particular issue or goal. They can take on activities which would exceed the capacity of individual institutions and the intention often is to establish a longer-term, more sustainable set of relationships than are typical in university-to-university twinning arrangements. This paper synthesises key lessons which have emerged from three recent efforts of establishing multi-university networks, one in Africa and two in Asia. Their experience suggests that such networks can be a useful mechanism for promoting a social and educational agenda while at the same time strengthening the capacity of participating universities. However, findings also suggest that success is not guaranteed. While university networks can expand resources and capabilities, they also increase operational complexity. The authors' analysis of the advantages and constraints encountered in the development and implementation of university networks aims to offer guidance to those pursuing this mechanism as a means of strengthening higher education and achieving broad development goals.