Emotional well-being of child care providers is important to the welfare of their young charges. Elevated depression and job-related stress may affect caregivers' ability to establish empathic connections with children. This study examined work conditions, job-related stress, and depression in 51 orphanage workers and 69 preschool teachers in Ukraine. Clinically significant levels of depressive symptoms were found in both groups. Hierarchical regression analyses showed that higher levels of perceived job resources and vacation use predicted lower depression. Predictors of perceived job resources included depression, perceived job control, and proportion of children between ages 2 and 3 in the group. A moderating effect of cognitive coping on the relationship between job control and job resources was found. This article informs interventions to promote positive development of children by identifying several factors that appear to reduce caregiver stress and depression.