The research-to-practice gap occurs when practices supported as effective by research are infrequently used in applied settings, such as classrooms. This gap may be due to teachers preferring to use practices they find to be trustworthy, usable, and accessible. Instead of relying on research, teachers frequently use resources from other teachers, which may be because teachers prefer practices that are supported by evidence developed in applied settings (i.e., practice-based evidence [PBE]). Using PBE to support the application of evidence-based practices (EBPs) may increase the latter's use in classrooms. In this chapter, we discuss the advantages and disadvantages of both EBPs and PBE and how the two can complement each other to help lessen the research-to-practice gap. We also discuss mixed-methods approaches that can be used to combine EBPs with PBE. [For the complete volume, "The Next Big Thing in Learning and Behavioral Disabilities. Advances in Learning and Behavioral Disabilities. Volume 31," see ED614920.]