This report presents the underlying theory and methodology of the first framework to operationalize culture and culturally responsiveness in the context of Positive Behavioral Interventions and Supports. Created following a systematic review of literature, this framework was created as a cultural artifact to expand the conceptualization of the role of culture in the implementation of PBIS and other education programs. The author hopes the framework will start a movement to address the systemic contradictions that researchers and practitioners in the field experience regarding racial disparities in behavioral and academic opportunities and outcomes and the locally meaningful implementation of PBIS and other top-to-bottom initiatives and programs (e.g., Response to Intervention [RTI]).