A comparative education analysis between the competence-based curriculum deployed at the Deusto University and the Tiradentes University was done. The analysis has focused on the following aspects: Educational theories; Curriculum design; Psycho-pedagogical guidelines; Teaching, learning and evaluation methodologies; Planning of execution; Results/Impacts. The set of information of the Tiradentes University was coming from a pilot project on the implementation of competence-based education, which was conducted by the authors of this article during 2012 and 2013. The data and information from the Deusto University were collected from: reading of institutional and course documents (Administration and Company Direction); Monitoring of classes; and interviews. The results indicated broad convergence of methodologies used and the contribution of both to the improvement of the quality indicators of the courses in these institutions. Moreover, in certain respects each institution has effective contributions of teaching-learning methodologies that can be embraced by the mutual enrichment of competence-based education as practiced by the two universities.