The National Strategy for the COVID-19 Response and Pandemic Preparedness provides a roadmap to guide America out of the worst public health crisis in a century. It outlines an actionable plan across the federal government to address the COVID-19 pandemic, including twelve initial executive actions issued by President Biden on his first two days in office. The National Strategy is organized around seven goals: (1) Restore trust with the American people; (2) Mount a safe, effective, and comprehensive vaccination campaign; (3) Mitigate spread through expanding masking, testing, data, treatments; health care workforce, and clear public health standards; (4) Immediately expand emergency relief and exercise the Defense Production Act; (5) Safely reopen schools, businesses, and travel while protecting workers; (6) Protect those most at risk and advance equity, including across racial, ethnic and rural/urban lines; and (7) Restore U.S. leadership globally and build better preparedness for future threats. To execute on the National Strategy, the White House will establish a COVID-19 Response Office responsible for coordinating the pandemic response across all federal departments and agencies. Through implementation of the National Strategy, the United States will make immediate progress on the seven goals. To monitor outcomes, the National Strategy includes the creation of publicly accessible performance dashboards, establishing a data-driven, evidence-based approach to evaluating America's progress in the fight against COVID-19. Full implementation of the National Strategy for COVID-19 will require sustained, coordinated, and complementary efforts of the American people, as well as groups across the country, including State, local, territorial, and Tribal governments; health care providers; businesses; manufacturers critical to the supply chain, communities of color, and unions. It will also require a global effort to contain the virus and advance health security. In collaboration with the people of this country, the United States government will lead an effective COVID-19 response that turns this crisis into a crucible, from which the nation will forge a stronger, better, and more equitable future.