Restraint and seclusion are crisis or emergency responses, which should only be used in extreme situations (e.g., a student engaging in repeated forceful physical aggression toward self or others) when risk of serious and imminent physical harm or injury is high and when an emergency response may reduce that risk. Restraint and seclusion are not planned or therapeutic interventions and should never be a routine part of a behavior support plan or used as a consequence for behavior. This practice brief defines restraint and seclusion, addresses prevalence, describes prevention approaches, and reviews policy implications.